An analysis of brain stem cells of people with autism spectrum disorder shows evidence of irregularities in very early brain development that may contribute to the neuropsychiatric disorder.

The findings support a concept scientists have long suspected: autism spectrum disorder (ASD) arises early in fetal development during the period when brain stem cells divide to form the elements of a functioning brain.

As reported in Stem Cell Reports, scientists examined brain stem cells—known as neural precursor cells (NPCs)—of people with ASD and found the NPCs—responsible for producing the three main kinds of brain cells: neurons, oligodendrocytes, and astrocytes—either overproduce or underproduce the number of permanent brain cells.

“The NPCs we studied from all samples showed abnormal proliferation, either ‘too little’ or ‘too much,’ which suggests that poor control of proliferation of brain cells is an important basis for ASD causation,” says study author Emanuel DiCicco-Bloom, a professor of neuroscience and cell biology and of pediatrics at Rutgers University Robert Wood Johnson Medical School.

“This study demonstrates at the cellular level that altered proliferation is indeed one likely mechanism of the disorder, supporting implications obtained from previous research.”

The study focused on the stem cell activity of five people with ASD, including those with idiopathic autism where there is no known genetic cause, and others with genetically defined 16p11.2 deletion. Those with macrocephaly, a medical term for an abnormally large head, had NPCs that produced too many brain cells. The remaining two people, who did not have macrocephaly, had NPCs that produced too few brain cells.

ASD is a neurodevelopmental disorder characterized by difficulties with social interactions and communication and the presence of repetitive and restricted behaviors. Most ASD cases are idiopathic. About 15% to 20% of ASD cases are caused by specific genetic mutations.

NPCs are formed prenatally during a period that stretches from the end of the first trimester through the second, about weeks eight to 24 of the 40-week gestation period of a human fetus.

“We’ve actually measured proliferation of human neural precursors and greatly advanced our understanding,” DiCicco-Bloom says. “In the future, once we have reproduced these studies and extended them, we also may be able to use this knowledge as a biomarker, which could signal when to introduce therapy, or to identify signaling pathways to target with drugs.”

Source: Rutgers University



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